What Is Hodgkin's lymphoma In Cancer

About Hodgkin's lymphoma

Lymphoma begins when healthy cells in the lymph system change and get out of control. This uncontrolled growth can form tumors, involve many parts of the lymphatic system, or spread to other parts of the body.

Hodgkin's lymphoma most often affects lymph nodes in the neck or between the lungs and in the posterior region of the sternum. It can also start in the lymph nodes in the armpit, groin, abdomen or pelvis.

If Hodgkin's lymphoma spreads, it may spread to the lungs, spleen, liver, bone marrow or bone. Hodgkin's lymphoma can spread to other parts of the body, but this is unusual.

Hodgkin's lymphoma types

There are different types of Hodgkin's lymphoma.
Knowing the type is important because it can affect how cancer is treated. You can find out about it as based on how the cell looks under the microscope and also whether cell contains certain abnormal proteins. Use a tissue biopsy to obtain these cells.

The American Joint Committee on Cancer (AJCC) recognizes two main categories of Hodgkin's lymphoma:
Classic Hodgkin's lymphoma, which is divided into 4 subtypes based on the structure of the lymph nodes and the appearance of the cells, and nodular lymphocytes Hodgkin's lymphoma.





Classic Hodgkin's Lymphoma (cHL)

CHL is the most common type of Hodgkin's lymphoma. About 95% of Hodgkin's lymphoma cases belong to the cHL category. CHL is diagnosed when characteristic abnormal lymphocytes (called Reed-Sternberg cells) are found. You should always contact the best Cancer Doctor In Delhi. 
CHL is divided into 4 subtypes:

Nodular sclerosis Hodgkin's lymphoma.
It affects up to 80% of people diagnosed with Classic Hodgkin Lymphoma. Nodular sclerosis Hodgkin lymphoma is most common in young people, especially women. In addition to Reed-Sternberg cells, connective tissue bands (called fibrosis) are found in lymph nodes. The presence of these bands can help diagnose this type of Hodgkin's lymphoma. This type of lymphoma usually affects the lymph nodes in the central part of the chest called the mediastinum.

Classical Hodgkin's lymphoma is rich in lymphocytes. About 6% of patients with cHL are diagnosed with classic Hodgkin's lymphoma that is rich in lymphocytes. It is common in men and usually affects areas other than the mediastinum. In addition to Reed-Sternberg cells, lymph node tissue contains many normal lymphocytes.

Mixed cellular Hodgkin lymphoma. This cHL subtype is most common in the elderly. It develops in the abdomen and carries many different cell types, including Reed-Sternberg cells.

Lymphocyte-poor Hodgkin's lymphoma. Lymphocyte-poor Hodgkin's lymphoma is the least common subtype of cHL. Only about 1% of cHL patients have this subtype. It is most common in older people. People with human immunodeficiency virus (HIV), which can cause acquired immunodeficiency syndrome (AIDS); and people in non-industrialized countries. Lymph nodes contain almost all Reed-Sternberg cells.

Nodular lymphocytic Hodgkin lymphoma

About 5% of patients with Hodgkin's lymphoma have Hodgkin's lymphoma dominated by nodular lymphocytes. It usually develops in lymph nodes in the neck, groin, or axilla.

Nodular lymphocyte-based Hodgkin's lymphoma is more similar to B-cell non-Hodgkin's lymphoma. People with this type of Hodgkin's lymphoma have large cells called "popcorn cells" or "LP cells" on the affected area with a marker called CD20 on their surface.


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